Corresponding author. Correspondence: Bharat B. Aggarwal, PhD. Tel: , Fax: , gro. This article has been cited by other articles in PMC.
|Published (Last):||4 March 2005|
|PDF File Size:||8.59 Mb|
|ePub File Size:||16.83 Mb|
|Price:||Free* [*Free Regsitration Required]|
Ajaikumar B. Robert A. Anderson Cancer Center, Houston, Texas Received August 19, ; Revised Manuscript Received September 27, ; Accepted September 28, Abstract: Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-in?
Major reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numerous approaches have been undertaken. These approaches involve,? The latter has been reported to have a rapid absorption with a peak plasma half-life.
Despite the lower bioavailability, therapeutic ef? Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease. Keywords: Curcumin; bioavailability; absorption; metabolism; formulations; adjuvants; nanoparticles; biocurcumax A. Introduction Curcumin, a hydrophobic polyphenol derived from the rhizome of the herb Curcuma longa has a wide spectrum of biological and pharmacological activities.
Chemically, curcumin is a bis-R, -unsaturated -diketone commonly called diferuloylmethane, Figure 1 , which exhibits keto—enol tautomerism having a predominant keto form in acidic and neutral solutions and stable enol form in alkaline medium. Traditionally, turmeric has been used for many ailments, particularly as an anti-in? Phone: E-mail: aggarwal mdanderson. Cytokine Research Laboratory. Pharmaceutical Development Center. Additionally, the hepato- and nephro-protective,11—13 thrombosis supressing,14 myocardial infarction protective,15—17 1 Aggarwal, B.
Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. Antioxidant activity of curcumin and related compounds. Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Lett. Involvement of the -diketone moiety in the antioxidative mechanism of tetrahydrocurcumin. Pharmacology of diferuloyl methane curcumin , a non-steroidal anti-in? Curcumin——a natural herb with antiHIV activity. Various animal models23,24 or human studies25—28 proved that curcumin is extremely safe even at very high doses.
For example, three different phase I clinical trials indicated that curcumin, when taken as high as 12 g per day, is well tolerated. In spite of its ef? Turmeric Curcuma longa and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen. Fungicidal property of Curcuma longa L. Food Chem.
Curcumin for malaria therapy. Potential anticancer activity of turmeric Curcuma longa. Cancer Lett , 29 2 , — Antihepatotoxic principles of Curcuma longa rhizomes. Planta Med. Curcumin attenuation of acute adriamycin myocardial toxicity in rats. Curcumin prevents adriamycin nephrotoxicity in rats. Antithrombotic effect of curcumin. Indian J. Protective role of curcumin against isoproterenol induced myocardial infarction in rats. Effect of curcumin on certain lysosomal hydrolases in isoproterenol-induced myocardial infarction in rats.
Effect of curcumin on blood sugar as seen in a diabetic subject. Hypolipidemic action of curcumin, the active principle of turmeric Curcuma longa in streptozotocin induced diabetic rats. Plant Foods Hum. Preliminary study on antirheumatic activity of curcumin diferuloyl methane. The purpose of this review is to discuss in detail the bioavailability, factors controlling bioavailability, and means to improve the bioavailability of curcumin.
Studies to date have suggested a strong intrinsic activity and, hence, ef? However, studies over the past three decades related to absorption, distribution, metabolism and excretion of curcumin have revealed poor absorption and rapid metabolism of curcumin that severely curtails its bioavailability. In this section, problems of curcumin bioavailability such as low serum levels, limited tissue distribution, apparent rapid metabolism and short half-life are described in detail. Serum Concentration.
One of the major observations related to curcumin studies involves the observation of extremely low serum levels. Toxicity studies on Alpinia galanga and Curcuma longa. Targeting events in melanoma carcinogenesis for the prevention of melanoma. Expert ReV. Anticancer Ther. Dose escalation of a curcuminoid formulation. BMC Complement Altern.
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Planta Med , 64 4 , — 6. Curcumin: the Indian solid gold. Clinical studies with curcumin. Structure of curcumin and its metabolites. A study on the fate of curcumin in the rat.
Acta Pharmacol. Copenhagen , 43 2 , 86— Absorption and tissue distribution of curcumin in rats. Toxicology , 16 3 , — Metabolism of curcumin— —studies with [3H]curcumin.
Toxicology , 22 4 , — With oral administration of 1. Entirely different plasma curcumin levels were found after i. Plasma curcumin levels peaked 2. Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab. Figure 2. Bioavailability of curcumin in rodents and man.
Bioavailability of curcumin in mice. The mice were sacri? The physical appearance and the HPLC pro? Oral administration of curcumin leads to its appearance in the serum of mice after just 1 h. Bioavailability of curcumin in human with and without piperine. Six healthy adult male human volunteers took 2 g of curcumin with or without 5 mg of piperine as bioperine in a cross-over design study. One week following initial drug administration, volunteers were crossed over to the opposite therapies, and blood samples were again obtained for evaluation.
Piperine-enhanced absorption of curcumin produced a near doubling of area under the curve AUC 8. Turmeric oil turmerne enhances bioavailability of curcumin. Biocurcumax is curcumin mixed with turmeric oil. Animal studies conducted in our own group showed detectable amounts of curcumin as shown by the HPLC pro? In contrast to rodents, oral dosing of 4—8 g of curcumin in humans showed peak plasma 35 Perkins, S; Verschoyle, R. Chemopreventive ef? Cancer Epidemiol. Biomarkers PreV. M after 1 h of dosing.
Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Cancer Res. Tissue Distribution.
Uptake and distribution of curcumin in body tissues is obviously important for its biological activity, yet only a limited number of studies have addressed this issue. Ravindranath et al.
Bioavailability of curcumin: problems and promises.
To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video. Quinine from Cinchona bark was used to treat the symptoms of malaria long before the disease was identified and the raw ingredients of a common…aspirin tablet have been a popular painkiller for far longer than we have had access to tablet-making machinery. And now, we know why. One of the ways our liver gets rid of foreign substances is by making them water-soluble so they can be more easily excreted, but this black pepper molecule inhibits that process. If you give people a bunch of turmeric curcumin, within an hour, you can see a little bump in the level in their bloodstream. Then, you see curcumin levels like this in the bloodstream.
COVID-19 Remote Access Support:
Ajaikumar B. Robert A. Anderson Cancer Center, Houston, Texas Received August 19, ; Revised Manuscript Received September 27, ; Accepted September 28, Abstract: Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-in? Major reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination.